Zeta Plus™ Brochure Datasheet by 3M Healthcare

Science. Applied to Life.'
Zeta Plus
Single-Use Depth Filtration
Product Portfolio
3M Purification Inc.
2Zeta Plus Single-Use Depth Filtration Product Portfolio
3M™ Zeta Plus™ Encapsulated System
The System of Choice for Single-Use Depth Filtration
Features & Benefits
Ergonomically Designed Holder System:
Model# 16EZB
Translucent plastic
shell (Standard
Capsules)
Easy detection of the liquid level inside,
providing real time monitoring of the
filtration process.
Solid core
design with fully
encapsulated shell
Eliminates the need for a stainless steel
housing and the cleaning step after
filtration.
Low hold-up volume.
Self guiding locking
mechanism
Fast, reliable and robust capsule-to-capsule
connectivity.
Lenticular style
capsule design
Linear scalability with filter surface area
from small to large systems for many fluid
challenges.
Consistency between single-use and
conventional depth filtration.
Both single and double layer Zeta Plus filter
media are available.
Excellent performance in throughput and
filtration efficiency.
Larger holders
(Model# 16EZB and
#16EZC [not shown])
are pivoted between
horizontal and
vertical positions
Enables loading and unloading at waist
height.
Minimal fluid spills when handling spent
capsules.
Single or two-stage depth filtration within
one filter holder.
Vertical flow path Full utilization of the filter media.
Small footprint during filtration.
Innovative Capsule/Manifold Design:
Zeta Plus filter media:
3
Zeta Plus Single-Use Depth Filtration Product Portfolio
The 3M™ Zeta Plus™ Encapsulated System is a
single-use depth filtration system designed for the
bioprocessing industry where upstream cell culture
clarification or downstream impurity removal is
required. The 3M Zeta Plus Encapsulated System
consists of three product lines: a pilot system that is
ideal for larger scale-up studies, and two systems that
are designed for production scale biomanufacturing.
The pilot and production systems are comprised of
a filter holder, top and bottom manifolds, and the
required number of capsules.
The 3M Zeta Plus Encapsulated Systems for
production scale biomanufacturing feature an
ergonomically designed large holder (Models# 16EZB
and 16EZC) that is pivoted between horizontal and
vertical positions, allowing for convenient loading and
unloading, minimal footprint during filtration, minimal
fluid spills during unloading, and full utilization of the
filter media.
The capsule design features a translucent plastic shell
(standard capsules) for easy liquid level detection; a
self guiding locking mechanism for fast and robust
capsule-to-capsule connection; and the Zeta Plus
depth filter media that provides excellent filtration
performance.
Zeta Plus™ Encapsulated
Standard Capsule Offering
With Polycarbonate Shells
Zeta Plus™ Encapsulated Capsule Offering
With Alkaline Resistant*
Polyphenylene Oxide / Polystyrene Shells
Zeta Plus™ Cartridges and Capsule Family
Self Guiding Locking Mechanism Enables
Fast And Robust Capsule-To-Capsule Connection
* Based on testing with 1M NaOH and 5% NaClO (Bleach).
See Chemical Compatibility Guide (70-0202-2023-5/LITPHG03) for more information.
4Zeta Plus Single-Use Depth Filtration Product Portfolio
High Performance filter media
The 3M™ Zeta Plus™ Encapsulated System utilizes the high
performing Zeta Plus depth filter series media, including the single and
dual (EXT) families covering a range of throughput, turbidity reduction,
anion exchange capacities, as well as media purity attributes. The
Zeta Plus EXT Series is a family of advanced dual zone depth filters
designed to provide excellent clarification of biological fluids. The EXT
Series filter media consist of two distinct layers, or “zones” of filter
media with the upstream zone more open than the downstream one.
This structure enhances the contaminant holding capacity of the filter
media and helps extend service life. The purification family designed
for lipid removal (Zeta Plus™ DELP series filters) is also available in the
capsule configuration.
Applications
Clarification of mammalian cell culture harvest.
Clarification of bacteria, yeast and insect cell lysates.
DNA reduction.
Endotoxin removal.
Anti-foaming agents removal.
The primary application for the 3M Zeta Plus Encapsulated System
is cell culture clarification after fermentation. The system can be
employed alone, or in combination with centrifugation or Tangential
Flow Filtration (TFF). Another application for the 3M Zeta Plus
Encapsulated System is downstream impurity removal. Taking
advantage of its positive charge capacity, Zeta Plus filter media has
been shown to be effective in reducing contaminants such as DNA
and endotoxins.
In monoclonal antibody production, Zeta Plus filter media is used
after the sequential Protein A column capture and low pH hold
viral inactivation steps to remove DNA-HCP aggregates prior to
subsequent ion exchange columns.
Ergonomically Designed Filter
Holders
Traditional depth filtration systems utilize lenticular style cartridge
filters and a vertical filtration flow path to allow easy access to process
liquids and efficient utilization of filter media. However, stacking
cartridges from bottom to top can be cumbersome, and dismantling
the spent cartridges is often labor intensive. Furthermore, fluid spills
during the unloading process could be problematic and, in some
instances, might expose the operators to the process fluids.
Zeta Plus™
Encapsulated
System
Zeta Plus™
Scale-Up
Capsules
Maximum
Operating Pressure
Inlet Pressure
Differential Pressure
3.4 bar (50 psi)
2.4 bar (35 psi)
3.1 bar (45 psi)
2.4 bar (35 psi)
Maximum
Operating
Temperature
40°C (104°F)
Pre-Use Flush or
Rinse
Preconditioning flush of the
system with a minimum of 54 L/
m2 of buffer or water is required
at temperature and pressure
not to exceed the maximum
values of corresponding product
configuration.
Table 1a. Recommended Operating Parameters
5
Zeta Plus Single-Use Depth Filtration Product Portfolio
Recognizing the need for a depth filtration system
that is fast, easy and clean, 3M designed filter holders
(Model# 16EZB and #16EZC) that can be pivoted
between the horizontal position for loading and
unloading the capsules and manifolds, and the vertical
position for filtration. Allowing loading and unloading
at waist height eliminates the need for operators to
lift capsules above their heads and reduces the risk of
fluid spills when handling spent capsules. The use of
the vertical flow path allows for full media utilization
and a small system footprint during filtration.
Small Holder (Model# 16EZA)
The small holder is available for laboratory and pilot scale-up studies,
in addition to low volume production filtration. The standard holder
can accommodate from one to four 0.23 m² capsules, or one 1.6 m²
(double layer) or 2.5 m² (single layer) capsule. Either single stage or
two-stage depth filtration can be performed within the same holder.
The standard small holder has a built-in torque limiter that will signal
the operator when the holder assembly is properly sealed. All 16EZA
holders have been designed to be fully autoclavable for applications
where that may be required.
Large Holder (Model# 16EZB)
The large holder can accommodate up to 17.5 m² of single layer Zeta
Plus filter media or 11.2 m² of double layer Zeta Plus filter media.
This holder is ideal for small to large production scale purification
processes.
Multi-Round Holder (Model #16EZC)
The Multi-Round Holder incorporates multiple carousels to allow for
additional filtration area for larger scale applications. Movement of
the carousel from the horizontal load position to the vertical filtration
position is done via automation. The Multi-Round Holder can be
adapted to meet the specific needs of large-scale biomanufacturers.
For more information, please contact your 3M Purification
representative.
16EZA
16EZB
16EZC
Figure 1. 3M™ Zeta Plus
Encapsulated System
6Zeta Plus Single-Use Depth Filtration Product Portfolio
Innovative Capsule/Manifold Design
Figure 2. Nominal Retention Ratings for Zeta Plus™ EXT Grades
(For reference only. Retention ratings may vary depending on application.)
* Based on testing with 1M NaOH and 5% NaClO (Bleach).
See Chemical Compatibility Guide (70-0202-2023-5/LITPHG03) for more information.
Top Manifold Bottom Manifold Single Cell Capsule
0.23 m² Capsule
(with double layer or single layer media)
Multi-Cell Capsule
1.6 m² Capsule (with double layer media)
2.5 m² Capsule (with single layer media)
Two capsule configurations are available for use with the 3M™ Zeta
Plus™ Encapsulated System. The single cell capsule is designed for
use with the small holder in laboratory and pilot scale-up studies.
It has 0.23 m² filtration area and accommodates both single and
dual layer Zeta Plus filter media. The multi-cell capsule is designed
for use with both the small and large holders. Each large capsule
accommodates 1.6 m² of EXT series dual layer media or 2.5 m² of
single layer media. The multi-cell capsule has a self guiding locking
mechanism for a fast, easy, and robust capsule-to-capsule connection,
and a solid core design that eliminates the need for stainless steel
bands and center post. In addition, this capsule also has two handles
for convenient loading and unloading, and a low capsule fill volume
and post-blown down hold-up volume. The capsule plastic shells are
available in two different materials for a broad range of applications.
The standard capsules use polycarbonate, which are translucent and
allow for easy liquid level detection. The alkaline resistant* capsules
use polyphenylene oxide/polystyrene, and can be used in applications
where NaOH is required after filtration. Correspondingly, the single-
use top and bottom manifolds are also available in these two materials.
The manifold set allows for the entire filtration process to be fast, easy,
and clean. An extra pair of manifolds is required to perform two-stage
filtration within one holder assembly.
ules '1': 5. Large Holder with Mechanical Po
7
Zeta Plus Single-Use Depth Filtration Product Portfolio
Scalability
Figure 3. The 3M™ Zeta Plus™ Encapsulated System Single-Use Depth Filtration Product Portfolio
Figure 4. Zeta Plus Scale-Up Capsules
Figure 5. Large Holder with Mechanical Polish Finish
Figure 6. Multi-Round System
BC25 (25 cm2)
E01020 (1020 cm²)
E0170 (170 cm²)
and
E0340 (340 cm²)
Small Holder
Double layer: 0.23 - 1.6 m²
Single layer: 0.23 - 2.5 m²
Large Holder
Double layer: 1.6 - 11.2 m²
Single layer: 2.5 - 17.5 m²
Multi-Round System Model
16EZC
Contact your 3M Purification
representative.
Four single-use scale-up capsules are available for media grade
selection and filter sizing. The BC25 capsule with 25 cm² filter media
is ideal for media grade screening. The scale-up capsule filters with
170 cm², 340 cm² and 1020 cm² media are designed for intermediate
scale-up studies and low volume production filtration. Combined with
these small scale capsules, the 3M Zeta Plus Encapsulated System
offers a completely single-use solution to process from 0.5 L to 2500+
L of liquid.
The 3M™ Zeta Plus™ Encapsulated System
retains the lenticular filter design and
vertical flow path that are characteristics of
traditional depth filtration systems, helping
provide consistent performance from
bench scale to production scale, and from
traditional lenticular to single-use systems.
Female Cunnecmv UpstveamVem a “CD a”, Fema‘e SlrawgmHandle Downstream Vem T~Hanme Capsme smn max aeCo ecor
8Zeta Plus Single-Use Depth Filtration Product Portfolio
Table 2a. 3M™ Zeta Plus™ Encapsulated System Capsule Filter and Manifold Specifications
Configuration
Single Cell Capsule Multi-Cell Capsule
Standard Alkaline Resistant1Standard Alkaline Resistant1
Dimensions (Height x Diameter) 5.7 cm x 45.2 cm (2.2” x 17.8”) 20.3 cm x 45.2 cm (8.0” x 17.8”)
Weight
Dry 3.3 kg (7 lbs) 3.4 kg (8 lbs) 10.0 kg (22 lbs) 10.7 kg (24 lbs)
Wet (post Blow-Down) 4.4 kg (10 lbs) 4.8 kg (11 lbs) 19.3 kg (43 lbs) 19.7 kg (43 lbs)
Materials of Construction
Filter Media Filter aids, cellulose, binding resin Filter aids, cellulose, binding resin
Outer Shell Polycarbonate Polyphenylene oxide
/ Polystyrene
Polycarbonate Polyphenylene oxide
/ Polystyrene
O-rings Silicone Silicone
Separators, Spacers and Connectors Polypropylene Polypropylene
Edge Seals Thermoplastic Elastomer Thermoplastic Elastomer
Handles N/A Nylon
Hold-up Volume
Capsule Fill
Volume2
Double Layer: ~ 1.1 L (~ 0.3 gal) ~ 5.2 L (~ 1.4 gal)
Single Layer: ~ 2.6 L (~ 0.7 gal) ~ 4.2 L (~1 .1 gal)
Post Blow-Down Hold-up Volume3< 100 mL (<0.026 gal) < 100 mL (<0.026 gal)
Maximum Operating Line Pressure 3.4 bar (50 psig) 3.4 bar (50 psig)
Maximum Differential Pressure
Forward 2.4 bar (35 psid) 2.4 bar (35 psid)
Sterilization 1 cycle autoclave: 30 min at 126°C (259°F) 1 cycle autoclave: 30 min at 126°C (259°F)
Effective Filtration Area 0.23 m² (2.4 ft²) Double layer: 1.6 m² (17.2 ft²)
Single layer: 2.5 m² (27.0 ft²)
Top/Bottom Manifold
Dimensions (Height x Diameter) 5.2 cm x 45.2 cm ( 2.0” x 17.8” ) 5.2 cm x 45.2 cm ( 2.0” x 17.8” )
Connector 1.5" Sanitary Style 1.5" Sanitary Style
Material Polycarbonate Polyphenylene oxide
/ Polystyrene
Polycarbonate Polyphenylene oxide
/ Polystyrene
Weight 4.5 kg (10 lbs) 4.5 kg (10 lbs) 4.5 kg (10 lbs) 4.5 kg (10 lbs)
Hold up volume < 250 mL (<0.07 gal) < 250 mL (<0.07 gal)
1 Based on testing with 1M NaOH and 5% NaClO (Bleach).
2 Capsule Fill Volume is defined as the volume of liquid that is required to fill the portion of the capsule outside the filter media.
3 Post Blow-Down Hold-up Volume is defined as the volume of the residual liquid after nitrogen gas blow-down.
Figure 7. Single-Use Manifolds and Capsule Filter Schematic
E16 Multi-Cell Capsule
1.6 m2 Capsule
(with double layer media)
2.5 m2 Capsule
(with single layer media)
Straight Handle
T-Handle
Female
Connector
E16 Single-Cell Capsule
0.23 m2 Capsule
(with double layer
or single layer media)
Plastic Shell
Capsule Stop
Bottom Manifold
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Top Manifold
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Downstream Vent
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9
Zeta Plus Single-Use Depth Filtration Product Portfolio
Table 2b. Zeta Plus™ Scale-Up Capsule Filter Specifications
170 cm² Capsule 340 cm² Capsule 1020 cm² Capsule
Dimensions
Height x Diameter 4.1” x 8.5” (10.3 cm x 21.6 cm) 6.0” x 8.5” (15.2 cm x 21.6 cm)
Weight
Dry - Single Layer 1.0 kg (2.2 lb) 1.0 kg (2.2 lb) 1.4 kg (3.0 lb)
Dry - Dual Layer 1.0 kg (2.2 lb) 1.0 kg (2.3 lb) 1.6 kg (3.5 lb)
Wet Post Blow-Down - Single Layer 1.1 kg (2.4 lb) 1.1 kg (2.5 lb) 1.8 kg (4.0 lb)
Wet Post Blow-Down - Double Layer 1.2 kg (2.6 lb) 1.3 kg (2.9 lb) 2.4 kg (5.2 lb)
Materials of Construction
Capsule Shells Polysulfone
Separator, Spacer, Vent Cap Polypropylene
O-ring Fluorocarbon
Endcap & Edge Seals Thermoplastic Elastomer
Volume
Capsule1 Fill Volume - Single Layer 0.48 L 0.40 L 0.91 L
Capsule1 Fill Volume - Double Layer 0.43 L 0.34 L 0.62 L
Post2 Blow-Down Hold-up Volume - Single Layer < 40 mL < 40 mL < 40 mL
Post2 Blow-Down Hold-up Volume - Double Layer < 40 mL < 40 mL < 40 mL
Miscellaneous
Sterilization 1 cycle autoclave: 30 min @ 126°C (259°F)
Effective Filtration Area 170 cm² (0.18 ft²) 340 cm² (0.37 ft²) 1020 cm² (1.10 ft²)
Connector 1/2” Sanitary Style
1 Capsule Fill Volume is defined as the volume of liquid that is required to fill the portion of the capsule outside the filter media.
2 Post Blow-Down Hold-up Volume is defined as the volume of the residual liquid after nitrogen gas blow-down.
IMPORTANT NOTICE: Always operate the filter system within the maximum differential pressure of 2.4 bar (35 psig).
Figure 8. Scale-Up Capsule Filter Schematics
170 cm & 340 cm
Capsules
1020 cm Capsule
Outlet
Inlet
Vent
Inlet
(Not Shown)
Outlet
Vent
10 Zeta Plus Single-Use Depth Filtration Product Portfolio
Table 3. 3M™ Zeta Plus™ Encapsulated System Holder Specifications
Table 4. 3M™ Zeta Plus Encapsulated System Holder Capacity
Figure 9. Small Standard Holder (Model# 16EZA) Dimensions
Holder Model
Small Holder
(Model# 16EZA)
Large Holder
(Model# 16EZB)
Multi-Round Holder
(Model# 16EZC)
Maximum Operating Pressure 3.4 bar (50 psi) 3.4 bar (50 psi) 3.4 bar (50 psi)
Materials of Construction
Frame 304 Stainless Steel 304 Stainless Steel Please contact your
3M Purification representative for
details.
End Plates 304 Stainless Steel 304 Stainless Steel
Support Rods 440 Stainless Steel 316 Stainless Steel
Stand 304 Stainless Steel 304 Stainless Steel
Hand Wheels 300 Series Stainless Steel 300 Series Stainless Steel
Gear Box N/A Epoxy Coated Cast Iron Cover
Shrouded in 304 Stainless Steel
Locking Bar N/A 304 Stainless Steel
Casters Stainless Steel Stainless Steel N/A
Wheels Phenolic Polyurethane
Surface Finish
Standard Mechanical Polish Finish
(4552601)
Mechanical Polish Finish
(6123502)
Please contact your
3M Purification representative for
details.
Special Electropolish Finish (4552602) N/A
Model Single Stage Two Stage
E16E01 Capsule E16E07/E16E11 Capsule E16E01 Capsule E16E07/E16E11 Capsule
16EZA 4 1 2 N/A
16EZB N/A 7N/A 6
148 cm
(58.38”)
Max
120 cm
(47.38”)
Min
169 cm
(65.38”)
Max
141 cm
(55.38”)
Min
121 cm
(47.48”)
Max
98 cm
(38.48”)
Min
65.6 cm
(25.81”)
65.6 cm
(25.81”)
65.6 cm
(25.81”)
zus 9cm {am Vertical Pnsilion
11
Zeta Plus Single-Use Depth Filtration Product Portfolio
Figure 10. Large Holder (Model# 16EZB) Dimensions
210.7 cm
(83”)
108.7 cm
(42.8”)
205.9 cm (81.1”)
Maximum
113.9 cm
(45.5”)
86.4 cm
(34.0”)
Horizontal Position
Vertical Position
Fm
12 Zeta Plus Single-Use Depth Filtration Product Portfolio
Ordering Guide
NOTES:
1. All Zeta Plus™ EXT media grades
are available for order.
2. For further information regarding
Zeta Plus EXT Series filter media,
please reference 3M Purification
Literature 70-0201-8862-2
(LITZPMEXT) or 70-0201-8863-0
(LITZPMEXTSP1).
3. DELP08A are Zeta Plus EXT grades
with two single layers of Delipid
(DEL) media.
4. Single layer 05SP media is offered
in 0.23 m² and 1.6 m² Capsule
format. One part number example is
E16E07A05SP.
Capsule Filter Ordering Information - Double layer (U.S. Customers)
Capsule Filter Ordering Information - Single layer (U.S. Customers)
Manifold Ordering Information
Filter Holder Ordering Information
Catalog
Number Configuration Number
of Cells
Gasket
Material Grade
E16
E - Standard
R - Alkaline
Resistant*
01 - 1 Cell
07 - 7 Cell A - Silicone
05SP01A
10SP02A
30SP02A
30SP03A
60SP01A
60SP02A
60SP03A
60SP05A
90SP05A
90SP08A
60LA05A
90LA05A
90LA08A
120ZB05A
120ZB08A
120ZB10A
60ZB05A
90ZB05A
90ZB08A
DELP08A
Catalog
Number Configuration Number
of Cells
Gasket
Material Grade
E16
E - Standard
R - Alkaline
Resistant*
01 - 1 Cell
11 - 11 Cell A - Silicone
30LA
50LA
60LA
90LA
10SP
30SP
50SP
60SP
90SP
30ZB
60ZB
90ZB
120ZB
DELP
Manifold Part 3M PI Part Number 3M ID
Manifold Set (Standard) 6128901 70020256221
Manifold Set (Alkaline Resistant*) 6129001 70020262369
Model Name 3M Catalog ID
(U.S. Customers) Description 3M ID
16EZA
4552601 Standard Pilot Holder 70020310846
4552602 Pilot Holder with
Electropolish Finish 70020310853
4552603 Pilot 2 High Holder 70020310861
4552604 Pilot 3 High Holder 70020310879
Model
Name
3M Catalog ID
(U.S.
Customers)
Description 3M ID
16EZB 6123502
Production
Holder with
Mechanical
Polish Finish
70020252899
3M Catalog ID
(U.S. Customers)
EFA
cm²
Material
Code Grade
E
0170
0340
1020
FSA
05SP01A
10SP02A
30SP02A
30SP03A
60SP01A
60SP02A
60SP03A
60SP05A
90SP05A
90SP08A
60LA05A
90LA05A
90LA08A
60ZB05A
90ZB05A
90ZB08A
120ZB05A
120ZB08A
120ZB10A
DELP08A
3M Catalog ID
(U.S. Customers)
EFA
cm²
Material
Code Grade
E
0170
0340
1020
FSA
05SP
10SP
30SP
50SP
60SP
90SP
30LA
50LA
60LA
90LA
30ZB
60ZB
90ZB
120ZB
DELP
Scale-Up Capsules - Double Layer
Scale-Up Capsules - Single Layer
* Based on testing with 1M NaOH
and 5% NaClO (Bleach). See
Chemical Compatibility Guide
(70-0202-2023-5/LITPHG03) for
more information.
13
Zeta Plus Single-Use Depth Filtration Product Portfolio
Capsule 3M ID Numbers for International Customers
3M™ Zeta Plus™ Encapsulated System Capsule Filters — Single Layer
3M™ Zeta Plus™ Encapsulated System Capsule Filters — Dual Layer
3M Catalog ID
(U.S. Customers)
3M ID
(International
Customers)
E16E01A05SP 70020288414
E16E01A10SP 70020288422
E16E01A30SP 70020288455
E16E01A50SP 70020274430
E16E01A60SP 70020288513
E16E01A90SP 70020288547
E16E01A30ZB 70020306992
E16E01A60ZB 70020307008
E16E01A90ZB 70020307024
E16E01A120ZB 70020306968
E16E01A30LP 70020288448
E16E01A50LP 70020288489
E16E01A60LP 70020288505
E16E01A90LP 70020288539
E16E01A30LA 70020288430
E16E01A50LA 70020288471
E16E01A60LA 70020288497
E16E01A90LA 70020288521
E16E01ADELI 70020256130
E16E01ADELP N/A
3M Catalog ID
(U.S. Customers)
3M ID
(International
Customers)
E16E01A05SP01A 70020239011
E16E01A10SP02A 70020239029
E16E01A30SP02A 70020238534
E16E01A30SP03A 70020239052
E16E01A60SP01A 70020239060
E16E01A60SP02A 70020239078
E16E01A60SP03A 70020239086
E16E01A60SP05A 70020239094
E16E01A90SP05A 70020239102
E16E01A90SP08A 70020239110
E16E01A60ZB05A 70020307016
E16E01A90ZB05A 70020307032
E16E01A90ZB08A 70020307040
E16E01A120ZB05A 70020309434
E16E01A120ZB08A 70020306976
E16E01A120ZB10A 70020306984
E16E01ADELI08A 70020256015
E16E01ADELP08A 70020285147
3M Catalog ID
(U.S. Customers)
3M ID
(International
Customers)
E16E07A05SP 70020288562
E16E11A10SP 70020288596
E16E11A30SP 70020288620
E16E11A50SP 70020288661
E16E11A60SP 70020288695
E16E11A90SP 70020288737
E16E11A30ZB 70020307149
E16E11A60ZB 70020307156
E16E11A90ZB 70020307164
E16E11A120ZB 70020307131
E16E11A30LP 70020288612
E16E11A50LP 70020288653
E16E11A60LP 70020288687
E16E11A90LP 70020288729
E16E11A30LA 70020288604
E16E11A50LA 70020288646
E16E11A60LA 70020288679
E16E11A90LA 70020288711
E16E11ADELI 70020288588
E16E11ADELP N/A
3M Catalog ID
(U.S. Customers)
3M ID
(International
Customers)
E16E07A05SP01A 70020236918
E16E07A10SP02A 70020236561
E16E07A30SP02A 70020236942
E16E07A30SP03A 70020236587
E16E07A60SP01A 70020236595
E16E07A60SP02A 70020236603
E16E07A60SP03A 70020236611
E16E07A60SP05A 70020236959
E16E07A90SP05A 70020236629
E16E07A90SP08A 70020236637
E16E07A60ZB05A 70020309376
E16E07A90ZB05A 70020307107
E16E07A90ZB08A 70020307115
E16E07A120ZB05A 70020307065
E16E07A120ZB08A 70020307073
E16E07A120ZB10A 70020307081
E16E07ADELI08A 70020256023
E16E07ADELP08A 70020285154
3M Catalog ID
(U.S. Customers)
3M ID
(International
Customers)
E16R01A05SP 70020288992
E16R01A10SP 70020288794
E16R01A30SP 70020288828
E16R01A50SP 70020288851
E16R01A60SP 70020288885
E16R01A90SP 70020288919
E16R01A30ZB 70020307198
E16R01A60ZB N/A
E16R01A90ZB 70020307222
E16R01A120ZB N/A
E16R01A30LP 70020288810
E16R01A50LP 70020288844
E16R01A60LP 70020288877
E16R01A90LP 70020288901
E16R01A30LA 70020288802
E16R01A50LA 70020288836
E16R01A60LA 70020288869
E16R01A90LA 70020288893
E16R01ADELI 70020288786
E16R01ADELP N/A
3M Catalog ID
(U.S. Customers)
3M ID
(International
Customers)
E16R01A05SP01A 70020262609
E16R01A10SP02A 70020262625
E16R01A30SP02A 70020262948
E16R01A30SP03A 70020262666
E16R01A60SP01A 70020262674
E16R01A60SP02A 70020262682
E16R01A60SP03A 70020262690
E16R01A60SP05A 70020262955
E16R01A90SP05A 70020262716
E16R01A90SP08A 70020262724
E16R01A60ZB05A 70020307214
E16R01A90ZB05A N/A
E16R01A90ZB08A 70020307248
E16R01A120ZB05A N/A
E16R01A120ZB08A 70020307172
E16R01A120ZB10A N/A
E16R01ADELI08A N/A
E16R01ADELP08A 70020285162
3M Catalog ID
(U.S.
Customers)
3M ID
(International
Customers)
E16R07A05SP 70020289008
E16R11A10SP 70020289024
E16R11A30SP 70020289057
E16R11A50SP 70020289099
E16R11A60SP 70020289123
E16R11A90SP 70020289164
E16R11A30ZB 70020307305
E16R11A60ZB N/A
E16R11A90ZB N/A
E16R11A120ZB N/A
E16R11A30LP 70020289040
E16R11A50LP 70020289081
E16R11A60LP 70020289115
E16R11A90LP 70020289156
E16R11A30LA 70020289032
E16R11A50LA 70020289073
E16R11A60LA 70020289107
E16R11A90LA 70020289149
E16R11ADELI 70020289016
E16R11ADELP N/A
3M Catalog ID
(U.S. Customers)
3M ID
(International
Customers)
E16R07A05SP01A 70020262740
E16R07A10SP02A 70020262757
E16R07A30SP02A 70020262799
E16R07A30SP03A 70020262807
E16R07A60SP01A 70020262815
E16R07A60SP02A 70020262823
E16R07A60SP03A 70020262831
E16R07A60SP05A 70020262849
E16R07A90SP05A 70020262864
E16R07A90SP08A 70020262872
E16R07A60ZB05A 70020309384
E16R07A90ZB05A 70020307289
E16R07A90ZB08A 70020307297
E16R07A120ZB05A N/A
E16R07A120ZB08A N/A
E16R07A120ZB10A N/A
E16R07ADELI08A N/A
E16R07ADELP08A 70020285170
14 Zeta Plus Single-Use Depth Filtration Product Portfolio
3M Catalog ID
(U.S.
Customers)
3M ID
(International
Customers)
E0170FSA05SP 70020290162
E0170FSA10SP 70020290188
E0170FSA30SP 70020290261
E0170FSA50SP 70020290329
E0170FSA60SP 70020290352
E0170FSA90SP 70020290444
E0170FSA30ZB 70020306729
E0170FSA90ZB 70020306752
E0170FSA30LA 70020290246
E0170FSA50LA 70020290303
E0170FSA60LA 70020290337
E0170FSA90LA 70020290428
3M Catalog ID
(U.S. Customers)
3M ID
(International
Customers)
E0340FSA05SP 70020290535
E0340FSA10SP 70020290550
E0340FSA30SP 70020290634
E0340FSA50SP 70020290691
E0340FSA60SP 70020290725
E0340FSA90SP 70020290816
E0340FSA30ZB 70020306810
E0340FSA60ZB 70020306828
E0340FSA90ZB 70020306844
E0340FSA30LA 70020290618
E0340FSA50LA 70020290675
E0340FSA60LA 70020290709
E0340FSA90LA 70020290790
3M Catalog ID
(U.S. Customers)
3M ID
(International
Customers)
E1020FSA05SP 70020290907
E1020FSA10SP 70020290923
E1020FSA30SP 70020291004
E1020FSA50SP 70020291061
E1020FSA60SP 70020291095
E1020FSA90SP 70020291186
E1020FSA30ZB 70020306901
E1020FSA60ZB 70020306919
E1020FSA90ZB 70020306935
E1020FSA30LA 70020290980
E1020FSA50LA 70020291046
E1020FSA60LA 70020291079
E1020FSA90LA 70020291160
3M™ Zeta Plus™ Encapsulated System Capsule Filters — Single Layer
3M Catalog ID
(U.S. Customers)
3M ID
(International
Customers)
E0170FSA05SP01A 70020290170
E0170FSA10SP02A 70020290204
E0170FSA30SP02A 70020290279
E0170FSA30SP03A 70020290287
E0170FSA60SP01A 70020290360
E0170FSA60SP02A 70020290378
E0170FSA60SP03A 70020290386
E0170FSA60SP05A 70020290394
E0170FSA90SP05A 70020290451
E0170FSA90SP08A 70020290469
E0170FSA60ZB05A 70020306745
E0170FSA90ZB05A 70020306760
E0170FSA90ZB08A 70020306778
E0170FSA120ZB05A 70020306695
E0170FSA120ZB08A 70020306703
E0170FSA120ZB10A 70020306711
E0170FSADELP08A 70020290154
3M Catalog ID
(U.S. Customers)
3M ID
(International
Customers)
E0340FSA05SP01A 70020290543
E0340FSA10SP02A 70020290576
E0340FSA30SP02A 70020290642
E0340FSA30SP03A 70020290659
E0340FSA60SP01A 70020290733
E0340FSA60SP02A 70020290741
E0340FSA60SP03A 70020290758
E0340FSA60SP05A 70020290766
E0340FSA90SP05A 70020290824
E0340FSA90SP08A 70020290832
E0340FSA60ZB05A 70020306836
E0340FSA90ZB05A 70020306851
E0340FSA90ZB08A 70020306869
E0340FSA120ZB08A 70020306794
E0340FSA120ZB10A 70020306802
E0340FSADELP08A 70020290527
3M Catalog ID
(U.S. Customers)
3M ID
(International
Customers)
E1020FSA05SP01A 70020290915
E1020FSA10SP02A 70020290949
E1020FSA30SP02A 70020291012
E1020FSA30SP03A 70020291020
E1020FSA60SP01A 70020291103
E1020FSA60SP02A 70020291111
E1020FSA60SP03A 70020291129
E1020FSA60SP05A 70020291137
E1020FSA90SP05A 70020291194
E1020FSA90SP08A 70020291202
E1020FSA60ZB05A 70020306927
E1020FSA90ZB05A 70020306943
E1020FSA90ZB08A 70020306950
E1020FSA120ZB05A 70020306877
E1020FSA120ZB08A 70020306885
E1020FSA120ZB10A 70020306893
E1020FSADELP08A 70020290899
3M™ Zeta Plus™ Encapsulated System Capsule Filters — Dual Layer
15
Zeta Plus Single-Use Depth Filtration Product Portfolio
Enabling Scalability
for Cell Culture Clarification
from R&D to Large-Scale Production
Laboratory / R&D
Up to 1 liter
Scale-Up
Up to 50 liters
Pilot Production
Up to 400 Liters
Large-Scale Production
Up to 5,000 Liters
Multi-Round Production
Up to 25,000 Liters
3M Purification Inc.
400 Research Parkway
Meriden, CT 06450 USA
Phone 1-800-243-6894
1-203-237-5541
Fax 1-203-630-4530
Web 3Mpurification.com
Please recycle. Printed in USA © 3M 2017.
3M and Zeta Plus are trademarks of
3M Company.
All rights reserved. 70-0202-3967-2 REV 0217
Limitation of Liability
Except where prohibited by law, 3M will not be liable for any loss or damage arising from the 3M product, whether
direct, indirect, special, incidental or consequential, regardless of the legal theory asserted, including warranty,
contract, negligence or strict liability.
Disclaimer
Information is correct to the best of our knowledge at the date of the publication. Before using a product sold by
3M, users are solely responsible for making their own independent determination that the product is suitable for the
intended use and can be used safely and legally. 3M MAKES NO WARRANTY; EXPRESS OR IMPLIED INCLUDING,
BUT NOT LIMITED TO, ANY IMPLIED WARRANTY OR CONDITION OF MERCHANTABILITY OR FITNESS FOR A
PARTICULAR PURPOSE OR ANY IMPLIED WARRANTY OR CONDITION ARISING OUT OF A COURSE OF DEALING,
CUSTOM OR USAGE OF TRADE.
Product Use
Intended uses: Manufacturing of pharmaceutical (drug) products, including active pharmaceutical ingredients and
vaccines.
Prohibited uses: As a component in a medical device that is regulated by any agency, and/or globally exemplary
agencies, including but not limited to: a) FDA, b) European Medical Device Directive (MDD), c) Japan Pharmaceuticals
and Medical Devices Agency (PMDA); Applications involving permanent implantation into the body; Life-sustaining
medical applications; Applications requiring FDA Food Contact compliance without use restrictions.